Framing the breakthrough technologies alongside functional goals would allow the Review to consider the opportunity cost of developing a technology more concretely. We have, and should, spend billions attempting to discover and distribute an effective cure for malaria — a critically important functional goal. But we must consider that alongside the cost of distributing mosquito nets, and understand that there are lives lost today for the hope of more lives saved in the future. While the Review focuses on cutting-edge technologies, it is important to acknowledge and highlight when there are other ways to effectively impact a functional goal.