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does anything matter? is not only a fundamental question, but it is one that can help remind us why we should be excited to wake up every day.
For this reason, I tend to not give much weight to arguments that argue against thinking in terms of optimization. If anything matters…, then optimization matters. It doesn’t mean that optimization needs to be single-minded (i.e. maximization). It only means that while there is such thing as an Opportunity Cost, optimization is desirable.
The question does anything matter? can seem unnecessary, like meaningless philosophical musing. To some degree it is. It can be easy to get lost looking for answers to human questions in the cosmos.